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A small trial in mixed hepatitis patients demonstrated that 480 mg silibinin daily for 7 days could significantly reduce aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltranspeptidase (GGT), and bilirubin, all markers of liver dysfunction (Buzzelli 1993)

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Studies found that PT-141 works for both males and females