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Several causative mutations in multiple genes have been described to date

Advances in the treatment of acute myeloid leukemia: new drugs and new challenges

For example, GSTA1 18 and mGSTA4 19 bind to JNK, and GSTM1 interacts with apoptosis signal-regulating kinase 1 (ASK1), the kinase transducing JNK signaling, to inhibit the apoptotic pathways

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Body weight considerations Unlike some peptides where dosing scales with body weight, cagrilintide uses fixed doses across weight categories in clinical trials

Thus far, a physiologically relevant signaling molecule capable of binding the pVSD remains to be identified