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As a selective growth hormone secretagogue, Ipamorelin is commonly examined for its interaction with the ghrelin (growth hormone secretagogue) receptor, GHS-R1a, and its downstream influence on endocrine signaling pathways associated with endogenous growth hormone regulation

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To assess the importance of lipidation modification to Cagri, pharmacological comparison of Cagri and its non-lipidated backbone (CagriBB) was undertaken using a cAMP response element (CRE)-reporter assay