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The glutamic-acid substitution sterically prevents binding to IGF-binding proteins (IGFBPs), leaving a far larger fraction of the peptide free to engage the IGF-1 receptor (IGF-1R)

Mishima et al., 2023)

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E-cadherin depletion destabilizes adherens junctions, facilitating cytoskeletal reorganization and mesenchymal marker expression, including -smooth muscle actin (-SMA)

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