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In Se deficiency, GPx activity decreases, degradation of H2O2 is reduced, thyroid cells are less resistant to oxidative stress, apoptosis and cell death occur ( 3 Se deficiency is one of the risk factors for many thyroid diseases 3.1 Se and Graves disease The main clinical manifestation of Graves disease (GD), also known as toxic diffuse goiter, is thyrotoxicosis caused by excessive production of thyroid hormones

Since GSH interacts with the 1st glutathione-interaction site, glutathionylated products of the random bi-uni mechanism might already adopt a suitable orientation as classical GSSR substrates for the subsequent deglutathionylation (Fig

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They can be kept at room temperature or refrigerated