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10.1161/CIRCULATIONAHA.113.007124 Circulation

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Conversely, this auto-oxidation, which is detrimental to the nitrosothiol formation, contributes to the production of highly reactive peroxynitrite resulting from the reaction between superoxide anions and NO

Accordingly, higher levels of caspase 3 activities were detected in the liver of Gstp1/2 / mice, and massive cell death was induced during liver dissociation performed to isolate hepatocytes (not shown)

Therefore, the most important function of GPX1-4 is to prevent oxidative stress by catalyzing the reduction of H 2 O 2 or organic hydroperoxides