The NHS provides evidence-based B12 replacement therapy for documented deficiency using standardised hydroxocobalamin protocols, but does not endorse lipotropic injections for weight management
Taking 5-amino-1mq in a fasted state may enhance fat oxidation, but taking it with food may reduce gastrointestinal discomfort
However, treating vitamin B12 deficiency can reduce fatigue and weakness, which may lead to an increased appetite in some individuals and indirectly contribute to weight gain
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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver
