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Atroshi, I., Gummesson, C., Johnsson, R

"If your body wants to snack, you did something wrong in the last meal," he says

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Patients may present with: Recurrent nosebleeds Heavy menstrual bleeding Easy bruising Gastrointestinal bleeding Surgical bleeding complications Iron deficiency anaemia Chronic fatigue The complexity of VWD contributes to these diagnostic challenges

The result is the formation of ROS (superoxide, hydrogen peroxide), which stimulates the downstream activation of matrix metalloproteinases -2 and -9