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Genetic factors such as p53 and nuclear factor erythroid 2-related factor 2 (Nrf2) also affect susceptibility by regulating the expression of solute carrier family 7 member 11 (SLC7A11) or influencing antioxidant defenses [92]

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For references and more information , see the section on cardiac arrhythmias in the Coffee article

Caffeine shows significant chronic psychoactive metabolite accumulation with daily use [34], while paraxanthine and 1-MX have mostly-inactive metabolites that are rapidly excreted [35]

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Several strategies minimize waste: Match reconstitution to usage rate