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Topical creams only do so much because they can't reach the deeper layers where collagen is produced

[114] This functionality is lost in vitamin B 12 deficiency, and can be measured clinically as an increased serum methylmalonic acid (MMA) concentration

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Progenitor Stem Cells (PSC) of Pinealocytes Promote regeneration of melatonin-producing cells, improving circadian entrainment and sleep quality