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There are several theories that suggest a connection between pernicious anemia and RA

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Most of these involve the stifle (knee) joint, where the cranial cruciate ligament, menisci, and articular cartilage work together and where the majority of canine orthopedic injuries occur: Cranial Cruciate Ligament Disease: The canine equivalent of human ACL tears, extremely common in medium to large breeds

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Specifically, it triggers the release of certain neurotransmitters in the hypothalamusthe part of the brain responsible for regulating hunger and thirst