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Another postmortem study has supported these findings by reporting a decreased expression of some subunits of complex I, III, IV, and V in the areas of the cingulate gyrus, motor cortex, and thalamus of the ASD subjects [122]

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doi: 10.1016/j.chom.2016.10.006

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AADvac1 ( 24 ) is the first tau vaccine to enter clinical trials, 469 aiming to inhibit tau aggregation, remove tau aggregates, prevent pathological spread, and slow disease progression

Cost-effectiveness Cost-effectiveness continues to be a key issue, as the raw materials (such as high-purity phospholipids and cholesterol), sterile manufacturing facilities, and specialised machinery considerably increase production costs relative to traditional formulations