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It has been shown to influence the expression of genes involved in angiogenesis (e.g., egr-1), stabilize endothelial integrity, and facilitate the recruitment of fibroblasts to injury sites 4

[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Prasun P, LoPiccolo MK, Ginevic I, et al

These gel sacs are frequent throughout many joints in the body such as the shoulder, knee and hip, and act as a soft cushion for a moving joint, helping to decrease friction and allow for better mobility

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However, its mode of action and cellular targets are poorly defined, and higher dosing and combination therapies are required to overcome resistance