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Overall, these results suggest that Mn overexposure triggers multiple programmed cell death pathways, including apoptosis and ferroptosis, through mitochondrial dysfunction, ER stress, and impaired redox balance

Mol Nutr Food Res 2015;59:1364-1372

Research has revealed that TB-500 possesses notable anti-inflammatory properties through modulation of cytokine production profiles and promotion of inflammatory resolution pathways

In summary, the development of pharmacological agents that promote itaconate production could potentially mitigate pathological inflammatory responses and prevent severe lung injury associated with TB progression

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The median incubation period for COVID-19 was estimated to be 5.1 days, and 99% (101 out of every 10,000 cases) will develop symptoms after 14 days 107,108