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and (3) aMD5 dimerized by the longest PEG11 linker (aMD5-PEG11) showed the highest activity, whereas the others were poor agonists (Fig

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Additionally, it has been proven to be effective in inhibiting B cell differentiation into plasma cells in the germinal center of lupus-prone mice, reduction of NLRP3 inflammasome activation mediated by AMPK, and blockade of pyroptosis of tubular epithelial cells in pristane-induced lupus mice (170)

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