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This is a common concern, borrowed from how suppressive hormones like exogenous testosterone behave

In hypertensive conditions, NO production is reduced, or its bioavailability decreases, resulting in enhanced vasoconstriction

Of course, effects of the neurotoxins themselves should be taken into consideration: 6-OHDA and MPTP are highly effective neurotoxins inhibiting respiratory processes leading to formation of free radicals and oxidative stress, which could extend beyond the dopaminergic neurons [218, 229]