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Because TB-500 builds up a systemic presence, a 4-week cycle ensures that the subject does not reach an over-saturated level where the actin-sequestering effect becomes counterproductive

10.4049/jimmunol.1001802

The paper also found that cancer cell lines showed a different response, appearing to rely more on an alternative lengthening of telomeres (ALT) mechanism rather than telomerase activation directly

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10.1016/j.jnutbio.2022.108943 13 Chinese Medical Association (2020)