Experiments are designed to quantify its effects on collagen I and III synthesis (via qPCR or Western blot), myofibroblast differentiation (by measuring -smooth muscle actin expression), and the critical MMP/TIMP balance
Its activity profile is best understood as systems-level: published in vitro and in vivo work has documented effects on fibroblast proliferation, collagen and growth-factor receptor expression, endothelial migration, nitric oxide system signalling, and dopamine and serotonin pathway markers
Functionally, Epithalon is hypothesized to exert its biological effects primarily through the activation of telomerase, an enzyme that adds specific DNA sequence repeats (TTAGGG in all vertebrates) to the 3 end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes
BOOSTED WITH VITAMIN C FOR MAXIMUM ABSORPTION: Each tablet combines L-Glutathione with Vitamin C, which enhances Glutathione bioavailability in the body while simultaneously boosting collagen synthesis for firmer, smoother, and more even-toned skin
Weekley CM, Harris HH (2013) Which form is that
Was sind die Folgen eines Glutathion-Mangels