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Furthermore, a substudy of the obesity trial investigated the mean relative change from baseline in liver fat at 24 and 48 weeks in 98 participants with MASLD at baseline

Start: Begin at 50 mg once daily to gauge tolerability (watch for flushing or GI upset)

doi: 10.1126/SCIADV.ABC5586 35 BarlowGLSchrchCMBhateSSPhillipsDJYoungADongSet al

Studies suggest subcutaneous administration achieves 7085% bioavailability compared to oral routes, though oral protocols at 100150mg compensate for first-pass metabolism

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