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Surprisingly, very similar prediction results with AUROC = 0.80 was established in this external validation cohort, suggesting that these microbiome features can be used to distinguish and predict human TMAO producer phenotypes from carnitine metabolism and have adequate potential to be applied in different populations

Clinical Nutrition, 38(4), 1747-1755

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are omega-3 polyunsaturated fatty acids (PUFAs) that can be obtained through diet or via conversion from dietary alpha-linolenic acid (ALA)

Significant improvements were also observed in key secondary endpoints including ACR50, ACR70, and DAS28-3 (CRP) (249)

This decline correlates with observable decreases in tissue repair capacity

Avoiding excessive use of laxatives is important, as they can lead to dependency and worsen constipation over time