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In this context, WD-driven dyslipidemia, low-grade mucosal inflammation, immune cell and glial activation, and microbiota-derived metabolites are best viewed as converging inputs that collectively amplify oxidative and iron stress within the ENS rather than as isolated parallel pathways

10.1021/ja01569a087 J

Individuals with compromised immune function or active infections should consult qualified healthcare providers for appropriate medical treatment

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This reduced output means skin loses structural support progressively, with wrinkles forming where the weakened matrix can no longer maintain smooth surface topology