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10.1155/2016/7432797 39 JahovicN.CevikH.SehirliA

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There is a great deal of evidence suggesting that DNA methylation defects are associated with ASDs, and the role of the methylenetetrahydrofolate reductase (MTHFR) gene in folate metabolism may contribute to epigenetic mechanisms that modify complex gene expression, thus causing autism

Pediatrics/adolescents safe levels have been evaluated in adults, but not in children

However, of the 5 studies included in the meta-analyses, 4 were assessed as having unclear or high risk of bias, making interpretation difficult

(2021) This placebo-controlled clinical study tested copper tripeptide serum in a double-blind design, providing the gold-standard clinical evidence that followed from this laboratory foundation