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such binding promotes osteoclast differentiation and osteolytic function in vitro Osteoclast differentiation is dependent on the citrullination of proteins by protein-arginine deiminases Both Fc-dependent and Fc-independent mechanisms are involved in ACPA-mediated osteoclast activation Binding of ACPAs to osteoclasts induces the production of the chemokine IL-8 Infusion of ACPAs into mice causes IL-8-dependent bone loss and IL-8-mediated pain behaviour The unique role of citrullination in osteoclast differentiation and ACPA-induced osteoclast activation might explain important features of the gradual development of rheumatoid arthritis, including why the joints are targeted Abstract A key unanswered question in the pathophysiology of rheumatoid arthritis (RA) is how systemic autoimmunity progresses to joint-specific inflammation

10.3109/19396368.2015.1115139 29 JohnsonN.PhillipsM

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However, the fact that AOXs are largely available over-the-counter with a reasonable price increases the risk that some patients can overmedicate with AOXs leading to detrimental effects

No mixing required, portable enough for travel, and easy to take at work or on the go

Declaration of Interest SJ has no conflicts of interest to declare