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Structurally, the core of the BBB is a monolayer of brain endothelial cells

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Despite some reports on the similarities between senescence and eryptosis at the morphological level [67], intracellular Ca 2+ elevation [74], Ca 2+ -driven activation of Gardos channels [70], PS exposure [76], or ROS contribution [71], senescence of erythrocytes cannot be considered an RCD of these cells and should be clearly distinguished from eryptosis

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*Correspondence: Ying Chen, [email protected] This article was submitted to Nutritional Immunology, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers