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These studies indicate the potential of utilizing the de novo pathway, a less extensively studied pathway, as a therapeutic strategy for metabolic diseases Barth syndrome is a rare disease caused by mutations in the tafazzin gene encoding for cardiolipin (CL), a phospholipid specific for the mitochondria 303

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These simulations reveal that valgus stress and axial loading significantly elevate the tension within the ligament, highlighting the critical points where failure is most likely to occur