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However, a breakthrough came with the observation that TICs, rather than the bulk of differentiated tumor cells, thrive in 3D gels [23, 24], offering an opportunity to uncover signaling pathways specific to TIC growth and identify TIC-specific therapeutic targets
Clin Toxicol (Phila) 2010
Our results revealed that the specific upregulated pathways in ESCC included cell cycle, glutathione metabolism, DNA replication, p53 signaling pathway, focal adhesion, small cell lung cancer, ECM-receptor interaction, pyrimidine metabolism, progesterone-mediated oocyte and drug metabolism (Figure 2b)
Washout in mice appears relatively fast given the short exposure window, but that is an animal-PK inference, not a human fact
Were not just innovating, she said