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For an official diagnosis of anemia, the red blood cells need to be below 4.14 and the hemoglobin levels below 13 g/dL The functional or optimal range for hemoglobin is 13.5 to 14.5 g/dL for women and 14 to 15 g/dL for men

Wesseling H, et al

In addition, the limit of volumes (25250 l) for nasal administration, influence of nasal pathologic conditions such as rhinitis and common cold on the absorption, and potential for nasal irritation by drug administration in the nasal cavity, are significant factors governing in the choice of the nasal route for drug application (Ozsoy et al., 2009

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