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5 Ferroptosis and the core pathology of AD 5.1 Ferroptosis and A plaques A misfolding and aggregation are key to AD pathology, with iron dysregulation promoting ferroptosis (111)

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Along with glutamine and glycine, it helps make and replenish glutathione

Lack of rest increases cortisol, which can lead to skin dullness and inflammation

The CD4+/CD8+ ratio serves as a key marker of immune system aging, with a shift toward CD8+ dominance often linked to chronic inflammation, reduced pathogen defense, and heightened all-cause mortality risk

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