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Depression models: P21 shows antidepressant-like effects in animal models of depression, potentially through neurogenesis enhancement and GSK-3 inhibition
Its also been studied as a potential ulcerative colitis treatment
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The researchers also suggested that The enhancement of wound closure was more pronounced (median of 89.2% compared with -10.3% for vehicle
Reviews of the rodent work note that the mechanism doesnt involve the hormonal suppression or receptor desensitization that would predict tolerance or rebound, and that adipose SAM levels tend to normalize rather than crash under inhibition
