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Additionally, cocaine induces apoptosis in cerebral vascular smooth muscle cells, contributing to vasoconstriction and ischemia, resulting in significant neurological damage ( 3.2 Neurological damage and psychiatric symptoms The neurological effects of cocaine include diffuse leukoencephalopathy, which is characterized by vasospasms, cerebral ischemia, and posterior reversible leukoencephalopathy (Rowbotham and Lowenstein, 1990

These symptoms differ from the mild, transient GI discomfort discussed earlier

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This call aims to generate robust clinical evidence and, where appropriate, data of regulatory relevance to support future regulatory interactions and subsequent clinical development

Long-term storage (months to years) : Store at -80C (ultra-low temperature freezer)

A rotator cuff issue would inject near the shoulder