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The relevance of this enzyme is illustrated by the fact that global SOD2 deficiency leads to neonatal death in mice ( c plus cytochrome c oxidase system ( Although the dismutation of superoxide by SOD2 is a predominant source of H 2 O 2 , there are other reactions that directly generate H 2 O 2 in mitochondria

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Nonetheless, dysregulation of autophagy may compromise cellular homeostasis and affect both, innate and adaptive immunity