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Black pigment gallstones are particularly associated with condition causing bilirubin overproduction or increased enterohepatic cycling [10]

1 Introduction Oxidative stress, i.e., overproduction of free radicals, is believed to be a significant predictor and/or a source of secondary pathologies in human disease

First, H 2 O 2 /O/OH can regulate the expression of genes related to nucleotide metabolism by transcriptionally regulating signaling pathways such as NRF2 and p53, thereby affecting the synthesis and degradation of nucleotides [206]