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The decline is not uniform, with marked differences across social classes

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Stores would also face tougher penalties for selling to minors, such as a longer probationary period for a violation, during which a series of offenses would trigger loss of a tobacco permit

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They found that sustained exposure to CC or ENDS caused a severe systemic inflammatory response, with increased activation of the NLRP3 inflammasome in neutrophils and macrophages, and enhanced dendritic cell-dependent activation of Th1 and Th17 cells in the lungs