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In acromegaly, the somatotropinoma in the anterior pituitary produces excessive amounts of growth hormone (GH)

All evidence comes from rodent models, cell cultures, or ex vivo tissue samples

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Therefore, appetite reduction, early fullness, constipation, diarrhea, and injection-site reactions may also be reported depending on the study

The requirement for cationic CPP in our study is consistent with findings from other studies, where CPPs with hydrophobic motifs did not significantly enhance cell uptake 60

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