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Signs of addiction include strong cravings, feeling anxious or irritable when you can't vape/use tobacco, continuing to use even when you want to quit, and needing more and more to get the same effect

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[53] tested the rate of pulmonary vascular endothelial cell apoptosis in lung tissue of eleven patients with COPD and ten patients with non-COPD squamous cell lung cancer, measured the expression of mitochondrial transcription factor (mtTFA) mRNA and protein and methylation of the mtTFA promoter

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