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Although tamoxifen and its metabolites (i.e., 4-hydroxytamoxifen) can cross the blood-brain barrier, these compounds have reduced bioavailability in the brain compared to other tissues 34

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[DOI] [PMC free article] [PubMed] [Google Scholar] Pellny TK, Locato V, Diaz Vivancos P, Markovic J, De Gara L, Pallard FV, Foyer CH