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Overexpression of RNF146 inhibits OGD/R-induced increases in MDA and Fe 2+ , as well as the expression of ferroptosis related genes

The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

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A small oral or sublingual dose is usually better tolerated than a large injection

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