Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4alpha in adult mice
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380 Activated ERK1/2 promotes a pro-regenerative phenotype by releasing HGF and Wnt, while activated AKT induces a profibrotic phenotype
In contrast, in vivo assayssuch as measurements of lipid peroxidation (MDA), antioxidant enzymes (SOD, CAT, GSH), and systemic oxidative stress markers (e.g., isoprostanes)provide a more realistic evaluation of a compounds biological effects
B-class plexins also activate and are activated by the receptor tyrosine kinases ErbB2 [30] and Met [31] and regulate axon pathfinding, cell morphology and cell motility [19] and have been implicated in many cancers, including prostate cancer [32]
