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Abstract Patients with ovarian cancer often respond well to combination chemotherapy initially but the majority eventually relapse when, with further treatment, the initially successful regimen proves ineffectual
1, Supplementary Fig
For example, lung cancer cell-lines show different sensitivities to doxorubicin in the form of GSH depletion, with A549 and GLC 4 210(S) cells experiencing approximately 50% and 64% GSH depletion after a 12 hour exposure to 70 nM and 5 nM (per million cells) respectively 37
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The genes encoding Cezanne (residues 53-446, E287K E288K), UbcH5c (residues 1-147), and E3C (residues 693-1083) were previously cloned into the pCold-SUMO expression vector 53
