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The pharmacologic reason for continued use in the case of both tobacco cigarettes and e-cigarettes is due to nicotines ability to trigger the release of neurotransmitters producing rewarding psychoactive effects such as dopamine [27]

Moreover, the advert claimed it was the most popular cigarette brand by doctors "from every branch of medicine." More doctors smoke camels than any other cigarette, advertisement for cigarettes in 1946

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The sound is gone, and with it some of the fury

16 percent for anti-tobacco education programs

Reynolds Tobacco Company Decision To Stop Using the Joe Camel Character in Tobacco Advertisements" (PDF)