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Moreover, several studies have demonstrated that the metabolic transition from OXPHOS to aerobic glycolysis mediated by Akt-mTOR-HIF-1 is the metabolic basis of TI (102, 116, 117) ( Figure 3 )

However, in some interventional studies, copper has been shown to exert a protective effect on diabetic patients, and a restricted copper diet can also induce steatosis in the liver [261,262,263]