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TPSA (topological polar surface area) is one of the most commonly used molecular descriptors in medicinal chemistry for predicting properties such as membrane permeability, transporter-mediated efflux, oral absorption, and CNS penetration

Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care

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Such drugs function as inhibitors, binding to the active site by mimicking the tetrahedral intermediate of its substrate, thus disabling the enzyme