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It can deliver glutathione to the cells efficiently, which improves the utilisation efficiency of glutathione in the body, allowing its physiological functions such as antioxidant and detoxification to be better performed

Finally, the C-terminal Neh3 domain is another transactivation domain that recruits chromo-ATPase/helicase DNA-binding protein 6 (CHD6), functioning as an NRF2 transcriptional coactivator [153] (Fig

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Additionally, the role of non-classical ferroptosis regulators (e.g., FSP1, DHODH, and GCH1/BH4) in DN is largely unexplored

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& Siddiqui, K