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The absorption of vitamin B12 is fraught with hurdles: In the stomach, vitamin B12 needs to bind with a protein called Intrinsic Factor to absorb, plus sufficient acid to release it from protein foods

The copper-bound form is what interacts with genes related to repair, antioxidant activity, and tissue integrity

I first encountered Wilson disease when I was a medical student at University of Chicago, working on a rotation in a medical ward

2002 Feb;133(2):167-70

Sterols are a group of lipids composed of four rigid hydrocarbon rings fused to a flexible hydrocarbon tail on one side and a hydroxyl group on the opposite side

Pro-fibrotic markers yes-associated protein 1 (YAP1) and taffazin (TAZ) and autophagy marker p62 showed elevated expression in Gclc L-KO mice (Fig