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A bibliographic search in MEDLINE/PubMed was carried out to collect clinical and pre-clinical research or review articles on EDs, and their main ingredients (caffeine, taurine, etc.), from 1987 to September 2022

I have sensitive skin

This product is intended for cosmetic and aesthetic use only and makes no medical claims.

Not only do they have low immunogenicity but they can also be easily synthesised and handled [188]

The clinical result is faster visible improvement with less redness and downtime than equivalent treatments that stimulate collagen without the anti-inflammatory component

Practical Implication: This research validates that topical GHK-Cu formulations achieve meaningful tissue concentrations, supporting the rationale for both cosmetic and research applications