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CRS is characterized by fulminant activation of a large number of lymphocytes that release inflammatory cytokines and result in severe tissue damage with multi-organ dysfunction syndrome (MODS) 97

Due to the lack of human studies with CJC-1295 no DAC, it is difficult to estimate how long the peptide should be administered or cycled

If raw materials are manufactured without strict GMP controls and not tested for endotoxins, LPS contamination is possible

Similar context-dependent outcomes have been described in models of traumatic brain injury, where astrocytic reactivity initially limits tissue damage but later contributes to glial scar formation and synaptic dysfunction 38,39

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doi: 10.1038/35058528