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233 A small molecule IKK2 inhibitor is under development as a therapy for inhibiting the NF-B activity

We examined several E3 ubiquitin ligases of PPAR and found that only NEDD4 was upregulated in our model (Fig

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Although glutamine is required as an alternative fuel for the tricarboxylic acid cycle (TCA) to produce ATP, it also contributes to a wide range of pathways in cells, producing amino acids, nucleotides and fatty acids as well as playing an important role in reactive oxygen species (ROS) homeostasis, mTOR activation and the hexosamine biosynthesis pathway (Figure 1)

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