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Monitoring Required: Observe patients for any side effects, particularly if receiving high doses or prolonged treatment
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Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses
It depends on how severe the deficiency is, the dose, and how the body responds
Sleep apnea and heart blocks are contraindications for ozanimod but not tofacitinib
