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308 The resulting Arg-CysO 2 (H) acts as an N-degron, which is identified by UBR1 and UBR2 for ubiquitylation and subsequent degradation

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However, as with other novel obesity drugs, Mazdutide must overcome certain challenges, such as optimizing dose-escalation strategies to reduce dropout rates due to adverse events, and ensuring consistent and sustained efficacy in larger scale clinical studies

Mice were then transferred to a 6 C cold chamber at 10 weeks of age

ElFeky et al., 2025