In parallel, we address the emerging field of chrononutrition, emphasizing that the timing of food intake and consumption of melatonin-rich or polyphenol-containing foods can enhance circadian rhythmicity, improve sleep quality, and reduce age-related metabolic and oxidative stress
In the absence of a unified conceptual framework, distinctions between neuroprotection, symptomatic treatment, and disease modification often become obscured, risking the conflation of mechanistic plausibility with demonstrable clinical benefit
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At pathological level, ROS becomes highly reactive, causing substantial damage to various cellular biomolecules such as nucleic acids, proteins and lipids (41)
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Biochem/physiol Actions Glutathione reductase IGR) is a crucial flavoenzyme in the antioxidant defense system
